Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC073
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-11-28 12:39
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment tbl Madopar 1+1/2+1+1/2 caps Madopar HBS 2 uvece tbl PK Mertz 1+1+0 tbl Mirapexin a 1,05mg 1x1 old patient

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 34 individuals with a value less than 0.65 were subsequently diagnosed with PD. That is, 80.95% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.65 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 26, 'TN': 22, 'TP': 16, 'FP': 8}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 24, 'TN': 20, 'TP': 18, 'FP': 10}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 41, 'TN': 29, 'TP': 1, 'FP': 1}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 5, 'TN': 3, 'TP': 37, 'FP': 27}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 9.56
timePerCircleCoV 0.435231
timePerCircleSlope -0.101585
meanError 3.93242
tremorFreq 6.64062
tremorRelPower 28.1334
tremorGyroAmpMean 0.0169715
tremorGyroAmpSlope 0.000109449
tremorGyroAmpCoV 0.418737
tremorCoordAmpMean 0.0409627
tremorCoordAmpSlope -0.000780191
tremorCoordAmpCoV 0.414341
tremorAccAmpMean 0.0299476
tremorAccAmpSlope 0.00197386
tremorAccAmpCoV 0.32117
tremorPcRelVar 0.593784
tremorPcX -0.533261
tremorPcY 0.84595

Circle Segment 1

Duration 14.24 s, Accuracy Estimate 3.977 (lower is better)

Circle Segment 2

Duration 19.2 s, Accuracy Estimate 2.371 (lower is better)

Circle Segment 3

Duration 10.52 s, Accuracy Estimate 2.126 (lower is better)

Circle Segment 4

Duration 6.88 s, Accuracy Estimate 2.984 (lower is better)

Circle Segment 5

Duration 6.56 s, Accuracy Estimate 3.336 (lower is better)

Circle Segment 6

Duration 8.28 s, Accuracy Estimate 2.645 (lower is better)

Circle Segment 7

Duration 9.2 s, Accuracy Estimate 6.41 (lower is better)

Circle Segment 8

Duration 6.24 s, Accuracy Estimate 6.987 (lower is better)

Circle Segment 9

Duration 7.64 s, Accuracy Estimate 3.484 (lower is better)

Circle Segment 10

Duration 6.84 s, Accuracy Estimate 5.005 (lower is better)

Spiral

numSpirals 7
timePerSpiralMean 35.1829
timePerSpiralCoV 0.390865
timePerSpiralSlope 0.112352
meanError 3.85954
tremorFreq 6.54297
tremorRelPower 38.1276
tremorGyroAmpMean 0.0238817
tremorGyroAmpSlope 0.00133366
tremorGyroAmpCoV 0.399983
tremorCoordAmpMean 0.03317
tremorCoordAmpSlope -0.000864891
tremorCoordAmpCoV 0.371984
tremorAccAmpMean 0.0248619
tremorAccAmpSlope 0.000366639
tremorAccAmpCoV 0.383319
tremorPcRelVar 0.668733
tremorPcX -0.739705
tremorPcY -0.672932

Spiral Segment 1

Duration 23.2 s, Accuracy Estimate 6.426 (lower is better)

Spiral Segment 2

Duration 22.6 s, Accuracy Estimate 6.351 (lower is better)

Spiral Segment 3

Duration 19.28 s, Accuracy Estimate 6.479 (lower is better)

Spiral Segment 4

Duration 55.28 s, Accuracy Estimate 1.94 (lower is better)

Spiral Segment 5

Duration 46.96 s, Accuracy Estimate 1.94 (lower is better)

Spiral Segment 6

Duration 39.08 s, Accuracy Estimate 1.782 (lower is better)

Spiral Segment 7

Duration 39.88 s, Accuracy Estimate 2.099 (lower is better)

Elel

eDurationMean 0.668194
eDurationStd 0.163223
eDurationStdnorm 0.244274
eDurationMedian 0.6725
eDurationQuartdelta 0.2575
eDurationQuartdeltanorm 0.3829
eDurationKurt 2.02947
eDurationTrenddiff -0.185
eDurationTrendratio 0.751678
eWidthMean 3.04525
eWidthStd 1.27263
eWidthStdnorm 0.417907
eWidthMedian 2.7495
eWidthQuartdelta 1.2285
eWidthQuartdeltanorm 0.446809
eWidthKurt 5.21524
eWidthTrenddiff -0.468
eWidthTrendratio 0.846154
eHeightMean 6.7145
eHeightStd 1.94562
eHeightStdnorm 0.289763
eHeightMedian 6.318
eHeightQuartdelta 2.3985
eHeightQuartdeltanorm 0.37963
eHeightKurt 7.83527
eHeightTrenddiff -0.4095
eHeightTrendratio 0.93913
eAspectMean 0.456037
eAspectStd 0.146386
eAspectStdnorm 0.320996
eAspectMedian 0.435315
eAspectQuartdelta 0.18481
eAspectQuartdeltanorm 0.424543
eAspectKurt 2.77548
eAspectTrenddiff -0.118701
eAspectTrendratio 0.760636
eSlantMean -0.0648995
eSlantStd 0.218526
eSlantStdnorm -3.36714
eSlantMedian -0.0267794
eSlantQuartdelta 0.310245
eSlantQuartdeltanorm -11.5852
eSlantKurt 2.69268
eSlantTrenddiff -0.0887932
eRtopMean 0.773455
eRtopStd 0.178821
eRtopStdnorm 0.231197
eRtopMedian 0.787856
eRtopQuartdelta 0.20482
eRtopQuartdeltanorm 0.259972
eRtopKurt 10.7727
eRtopTrenddiff 0.0757081
eRbotMean 1.05434
eRbotStd 0.632748
eRbotStdnorm 0.600134
eRbotMedian 0.887879
eRbotQuartdelta 0.509109
eRbotQuartdeltanorm 0.5734
eRbotKurt 4.02596
eRbotTrenddiff 0.280093
eRrightMean 0.895843
eRrightStd 0.0690483
eRrightStdnorm 0.0770763
eRrightMedian 0.913002
eRrightQuartdelta 0.106916
eRrightQuartdeltanorm 0.117103
eRrightKurt 1.95241
eRrightTrenddiff 0.0512414
eRleftMean 0.415424
eRleftStd 0.189289
eRleftStdnorm 0.455652
eRleftMedian 0.398701
eRleftQuartdelta 0.245733
eRleftQuartdeltanorm 0.616333
eRleftKurt 3.56385
eRleftTrenddiff 0.158016
lDurationMean 0.841111
lDurationStd 0.237105
lDurationStdnorm 0.281895
lDurationMedian 0.7375
lDurationQuartdelta 0.365
lDurationQuartdeltanorm 0.494915
lDurationKurt 2.77415
lDurationTrenddiff -0.2075
lDurationTrendratio 0.766854
lWidthMean 4.62475
lWidthStd 1.71259
lWidthStdnorm 0.370309
lWidthMedian 4.329
lWidthQuartdelta 2.574
lWidthQuartdeltanorm 0.594595
lWidthKurt 2.46209
lWidthTrenddiff -1.3455
lWidthTrendratio 0.755319
lHeightMean 14.4398
lHeightStd 3.19921
lHeightStdnorm 0.221556
lHeightMedian 13.0455
lHeightQuartdelta 4.563
lHeightQuartdeltanorm 0.349776
lHeightKurt 2.37195
lHeightTrenddiff -3.1005
lHeightTrendratio 0.802974
lAspectMean 0.317877
lAspectStd 0.0937121
lAspectStdnorm 0.294806
lAspectMedian 0.324048
lAspectQuartdelta 0.117973
lAspectQuartdeltanorm 0.364059
lAspectKurt 2.85355
lAspectTrenddiff -0.0613022
lAspectTrendratio 0.823104
lSlantMean 0.0982201
lSlantStd 0.122264
lSlantStdnorm 1.2448
lSlantMedian 0.0918646
lSlantQuartdelta 0.203821
lSlantQuartdeltanorm 2.21871
lSlantKurt 2.10826
lSlantTrenddiff -0.147115
lRtopMean 0.894736
lRtopStd 0.0971414
lRtopStdnorm 0.10857
lRtopMedian 0.933866
lRtopQuartdelta 0.0974909
lRtopQuartdeltanorm 0.104395
lRtopKurt 5.92415
lRtopTrenddiff 0.0167779
lRbotMean 0.669778
lRbotStd 0.373904
lRbotStdnorm 0.558251
lRbotMedian 0.62291
lRbotQuartdelta 0.443641
lRbotQuartdeltanorm 0.712208
lRbotKurt 4.64742
lRbotTrenddiff 0.348339
lRrightMean 0.946735
lRrightStd 0.0612562
lRrightStdnorm 0.0647025
lRrightMedian 0.968951
lRrightQuartdelta 0.0504981
lRrightQuartdeltanorm 0.0521163
lRrightKurt 6.35078
lRrightTrenddiff -0.0123916
lRleftMean 0.310152
lRleftStd 0.129787
lRleftStdnorm 0.418463
lRleftMedian 0.264706
lRleftQuartdelta 0.171542
lRleftQuartdeltanorm 0.648046
lRleftKurt 4.64941
lRleftTrenddiff 0.00945075

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

Elel Segment 11

Elel Segment 12

Elel Segment 13

Elel Segment 14

Elel Segment 15

Elel Segment 16

FITTS Short Modified

meanTouchScore 1
sumTouchScores 3
meanMovementTime 0.7625
numTouches 3
undershootPercentage 0
overshootPercentage 0

FITTS Long Modified

meanTouchScore 0.72296
sumTouchScores 13.7362
meanMovementTime 1.09694
numTouches 19
undershootPercentage 10.5263
overshootPercentage 31.5789

ZigZag

numZigzags 5
timePerZigzagMean 56.096
timePerZigzagCoV 0.135775
timePerZigzagSlope -0.0532658
meanError 2.0539
tremorFreq 6.44531
tremorRelPower 38.8894
tremorGyroAmpMean 0.0253886
tremorGyroAmpSlope 0.000790211
tremorGyroAmpCoV 0.378363
tremorCoordAmpMean 0.0298202
tremorCoordAmpSlope 0.000411071
tremorCoordAmpCoV 0.257208
tremorAccAmpMean 0.0285633
tremorAccAmpSlope 0.000261851
tremorAccAmpCoV 0.262537
tremorPcRelVar 0.6952
tremorPcX 0.513708
tremorPcY 0.857965

ZigZag Segment 1

Duration 69.08 s, Accuracy Estimate 2.128 (lower is better)

ZigZag Segment 2

Duration 54.52 s, Accuracy Estimate 1.925 (lower is better)

ZigZag Segment 3

Duration 49.44 s, Accuracy Estimate 2.092 (lower is better)

ZigZag Segment 4

Duration 52.08 s, Accuracy Estimate 2.057 (lower is better)

ZigZag Segment 5

Duration 55.36 s, Accuracy Estimate 2.068 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 24.992
timePerZigzagCoV 0.0930667
timePerZigzagSlope -0.0476953
zigzagHeightMean 58.6871
zigzagHeightCoV 0.0777854
zigzagHeightSlope 0.0157002
meanError 0.0471216
tremorFreq 6.54297
tremorRelPower 32.647
tremorGyroAmpMean 0.0265763
tremorGyroAmpSlope 0.00162902
tremorGyroAmpCoV 0.319183
tremorCoordAmpMean 0.0572258
tremorCoordAmpSlope 0.00349097
tremorCoordAmpCoV 1.4784
tremorAccAmpMean 0.0373993
tremorAccAmpSlope 0.00119757
tremorAccAmpCoV 0.317347
tremorPcRelVar 0.933944
tremorPcX -0.51154
tremorPcY -0.85926

ZigZag Offset Segment 1

Duration 27.36 s, Accuracy Estimate 0.074 (lower is better)

ZigZag Offset Segment 2

Duration 27.04 s, Accuracy Estimate 0.039 (lower is better)

ZigZag Offset Segment 3

Duration 22.96 s, Accuracy Estimate 0.033 (lower is better)

ZigZag Offset Segment 4

Duration 25.36 s, Accuracy Estimate 0.044 (lower is better)

ZigZag Offset Segment 5

Duration 22.24 s, Accuracy Estimate 0.045 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.76}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.65}
BM_May22 {‘BM_May22_class’: ‘PD’, ‘BM_May22_score’: 0.7046547813395034}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.8851098906460702}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.7978055543766501}